Southwest® flights from Des Moines to San Antonio from $176

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Low fares from Des Moines to San Antonio

$

Des Moines (DSM)to

San Antonio (SAT)
Depart: 10/29/2026

One-way

Basic

From
$176
Seen: 16 hrs ago

Des Moines (DSM)to

San Antonio (SAT)
Depart: 08/28/2026

One-way

Basic

From
$193
Seen: 20 hrs ago

Des Moines (DSM)to

San Antonio (SAT)
Depart: 10/29/2026

One-way

Choice

From
$216
Seen: 16 hrs ago

Des Moines (DSM)to

San Antonio (SAT)
Depart: 08/28/2026

One-way

Choice

From
$233
Seen: 20 hrs ago

Des Moines (DSM)to

San Antonio (SAT)
Depart: 10/29/2026

One-way

Choice Preferred

From
$286
Seen: 16 hrs ago

Des Moines (DSM)to

San Antonio (SAT)
Depart: 08/28/2026

One-way

Choice Preferred

From
$303
Seen: 20 hrs ago

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Explore flights from Des Moines to San Antonio

Aug 2026
From$193*
Seen: 20 hrs ago
One Way/Basic
Sep 2026
No result for this month.
Oct 2026
From$176*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $193
Displaying fares for August-2026
  • DSM–SAT, 08/01/2026: From $499
    01

    Sat

    AUG

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    02

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  • DSM–SAT, 08/04/2026: From $499
    04

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    05

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  • DSM–SAT, 08/06/2026: From $499
    06

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    07

    Fri

  • DSM–SAT, 08/08/2026: From $662
    08

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    09

    Sun

  • DSM–SAT, 08/10/2026: From $394
    10

    Mon

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    11

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  • DSM–SAT, 08/12/2026: From $394
    12

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  • DSM–SAT, 08/13/2026: From $394
    13

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    14

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    15

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    16

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    17

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    18

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    19

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    20

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    21

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    22

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    23

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    24

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    25

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    26

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    27

    Thu

  • DSM–SAT, 08/28/2026: From $193
    28

    Fri

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    29

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    30

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    31

    Mon

    • Range$193-$662

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    San Antonio International Airport
    Distance:
    870 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from Des Moines to San Antonio on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to San Antonio with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Antonio International Airport book yours with your flight.
    Yes! Flights from Des Moines to San Antonio—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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