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Find low faresSouthwest® flights from Des Moines to San Antonio from $159
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Low fares from Des Moines to San Antonio
$
Des Moines (DSM)to
San Antonio (SAT)
Depart: 02/25/2026
One-way
Basic
From
$159
Seen: 9 hrs ago
Des Moines (DSM)to
San Antonio (SAT)
Depart: 04/29/2026
One-way
Basic
From
$159
Seen: 16 hrs ago
Des Moines (DSM)to
San Antonio (SAT)
Depart: 04/01/2026
One-way
Basic
From
$159
Seen: 17 hrs ago
Des Moines (DSM)to
San Antonio (SAT)
Depart: 04/22/2026
One-way
Basic
From
$159
Seen: 13 hrs ago
Des Moines (DSM)to
San Antonio (SAT)
Depart: 03/28/2026
One-way
Basic
From
$171
Seen: 17 hrs ago
Des Moines (DSM)to
San Antonio (SAT)
Depart: 02/26/2026
One-way
Basic
From
$171
Seen: 16 hrs ago
Explore flights from Des Moines to San Antonio
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Flight Details
Departing from:
Des Moines Airport
Arriving at:
San Antonio International Airport
Distance:
870 miles
Route Information
71† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 71 weekly flights from Des Moines to San Antonio on Southwest Airlines.
To find the lowest fares by day and time to fly Des Moines to San Antonio with Southwest, check out our Low Fare Calendar.
You can rent a car at San Antonio International Airport book yours with your flight.
Yes! Flights from Des Moines to San Antonio—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.