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Find low faresSouthwest® flights from Des Moines to Jacksonville from $173
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Low fares from Des Moines to Jacksonville
$
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 02/25/2026
One-way
Basic
From
$173
Seen: 21 hrs ago
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 02/23/2026
One-way
Basic
From
$180
Seen: 20 hrs ago
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 04/23/2026
One-way
Basic
From
$180
Seen: 16 hrs ago
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 03/05/2026
One-way
Basic
From
$180
Seen: 16 hrs ago
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 03/07/2026
One-way
Basic
From
$180
Seen: 13 hrs ago
Des Moines (DSM)to
Jacksonville (JAX)
Depart: 04/03/2026
One-way
Basic
From
$204
Seen: 1 hour ago
Explore flights from Des Moines to Jacksonville
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Flight Details
Departing from:
Des Moines Airport
Arriving at:
Jacksonville International Airport
Distance:
1012 miles
Route Information
43† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 43 weekly flights from Des Moines to Jacksonville on Southwest Airlines.
To find the lowest fares by day and time to fly Des Moines to Jacksonville with Southwest, check out our Low Fare Calendar.
You can rent a car at Jacksonville International Airport book yours with your flight.
Yes! Flights from Des Moines to Jacksonville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.