Southwest® flights from Des Moines to New Orleans from $163

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Low fares from Des Moines to New Orleans

$

Des Moines (DSM)to

New Orleans (MSY)
Depart: 12/12/2026

One-way

Basic

From
$163
Seen: 12 hrs ago

Des Moines (DSM)to

New Orleans (MSY)
Depart: 11/16/2026

One-way

Basic

From
$163
Seen: 1 hour ago

Des Moines (DSM)to

New Orleans (MSY)
Depart: 11/11/2026

One-way

Basic

From
$163
Seen: 1 hour ago

Des Moines (DSM)to

New Orleans (MSY)
Depart: 11/14/2026

One-way

Basic

From
$168
Seen: 28 minutes ago

Des Moines (DSM)to

New Orleans (MSY)
Depart: 12/01/2026

One-way

Basic

From
$196
Seen: 17 hrs ago

Des Moines (DSM)to

New Orleans (MSY)
Depart: 12/04/2026

One-way

Basic

From
$199
Seen: 8 hrs ago

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Explore flights from Des Moines to New Orleans

Oct 2026
From$210*
Seen: 18 hrs ago
One Way/Basic
Nov 2026
From$163*
Seen: 1 hour ago
One Way/Basic
Dec 2026
From$163*
Seen: 12 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $210
Displaying fares for October-2026
  • DSM–MSY, 10/01/2026: From $351
    01

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    OCT

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  • DSM–MSY, 10/03/2026: From $305
    03

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  • DSM–MSY, 10/09/2026: From $351
    09

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  • DSM–MSY, 10/10/2026: From $305
    10

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    11

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  • DSM–MSY, 10/14/2026: From $259
    14

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    15

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  • DSM–MSY, 10/16/2026: From $259
    16

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    21

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  • DSM–MSY, 10/22/2026: From $237
    22

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    23

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    24

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    25

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    26

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    27

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  • DSM–MSY, 10/29/2026: From $210
    29

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    30

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    • Range$210-$351

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Louis Armstrong International Airport
    Distance:
    818 miles

    Route Information

    68† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 68 weekly flights from Des Moines to New Orleans on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to New Orleans with Southwest, check out our Low Fare Calendar.
    You can rent a car at Louis Armstrong International Airport book yours with your flight.
    Yes! Flights from Des Moines to New Orleans—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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