Southwest® flights from Des Moines to San Diego from $189

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Low fares from Des Moines to San Diego

$

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/05/2026

One-way

Basic

From
$189
Seen: 21 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 01/19/2027

One-way

Basic

From
$194
Seen: 21 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 02/10/2027

One-way

Basic

From
$194
Seen: 10 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 01/12/2027

One-way

Basic

From
$194
Seen: 19 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/24/2026

One-way

Basic

From
$214
Seen: 1 hour ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 01/28/2027

One-way

Basic

From
$214
Seen: 13 hrs ago

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Explore flights from Des Moines to San Diego

Nov 2026
From$314*
Seen: 11 hrs ago
One Way/Basic
Dec 2026
From$189*
Seen: 21 hrs ago
One Way/Basic
Jan 2027
From$194*
Seen: 19 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $189
cmp-daily-histogram-bars-legend-max-price-aria-label $574
Displaying fares for November-2026
  • DSM–SAN, 11/11/2026: From $574
    11

    Wed

    NOV

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • DSM–SAN, 11/13/2026: From $574
    13

    Fri

  • DSM–SAN, 11/14/2026: From $574
    14

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • DSM–SAN, 11/18/2026: From $489
    18

    Wed

  • DSM–SAN, 11/19/2026: From $489
    19

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • DSM–SAN, 11/21/2026: From $484
    21

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • DSM–SAN, 11/23/2026: From $489
    23

    Mon

  • DSM–SAN, 11/24/2026: From $489
    24

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    25

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • DSM–SAN, 11/27/2026: From $314
    27

    Fri

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • DSM–SAN, 11/29/2026: From $428
    29

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    DEC

  • DSM–SAN, 12/02/2026: From $214
    02

    Wed

  • DSM–SAN, 12/03/2026: From $229
    03

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • DSM–SAN, 12/05/2026: From $189
    05

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • DSM–SAN, 12/10/2026: From $214
    10

    Thu

    • Range$189-$574

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1428 miles

    Questions we hear the most

    There are 76 weekly flights from Des Moines to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Des Moines to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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