Southwest® flights from Des Moines to San Diego from $135

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Low fares from Des Moines to San Diego

$

Des Moines (DSM)to

San Diego (SAN)
Depart: 11/16/2026

One-way

Basic

From
$135
Seen: 8 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/05/2026

One-way

Basic

From
$135
Seen: 15 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/09/2026

One-way

Basic

From
$135
Seen: 6 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/11/2026

One-way

Basic

From
$156
Seen: 3 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 11/16/2026

One-way

Choice

From
$182
Seen: 8 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 12/09/2026

One-way

Choice

From
$182
Seen: 6 hrs ago

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Explore flights from Des Moines to San Diego

Oct 2026
From$484*
Seen: 9 hrs ago
One Way/Basic
Nov 2026
From$135*
Seen: 8 hrs ago
One Way/Basic
Dec 2026
From$135*
Seen: 15 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $135
cmp-daily-histogram-bars-legend-max-price-aria-label $569
Displaying fares for October-2026
  • DSM–SAN, 10/22/2026: From $569
    22

    Thu

    OCT

  • DSM–SAN, 10/23/2026: From $569
    23

    Fri

  • DSM–SAN, 10/24/2026: From $569
    24

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    25

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    26

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    27

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    28

    Wed

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    29

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    30

    Fri

  • DSM–SAN, 10/31/2026: From $484
    31

    Sat

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    01

    Sun

    NOV

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • DSM–SAN, 11/03/2026: From $309
    03

    Tue

  • DSM–SAN, 11/04/2026: From $309
    04

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    05

    Thu

  • DSM–SAN, 11/06/2026: From $309
    06

    Fri

  • DSM–SAN, 11/07/2026: From $309
    07

    Sat

  • DSM–SAN, 11/08/2026: From $309
    08

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    10

    Tue

  • DSM–SAN, 11/11/2026: From $259
    11

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • DSM–SAN, 11/16/2026: From $135
    16

    Mon

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    17

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

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    19

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    20

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  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

    • Range$135-$569

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1428 miles

    Questions we hear the most

    There are 76 weekly flights from Des Moines to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Des Moines to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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