Southwest® flights from Des Moines to San Diego from $178

Promo Code

Low fares from Des Moines to San Diego

$

Des Moines (DSM)to

San Diego (SAN)
Depart: 09/12/2026

One-way

Basic

From
$178
Seen: 19 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 09/11/2026

One-way

Basic

From
$178
Seen: 17 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 09/19/2026

One-way

Basic

From
$178
Seen: 22 minutes ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 11/03/2026

One-way

Basic

From
$178
Seen: 1 hour ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 09/05/2026

One-way

Basic

From
$178
Seen: 5 hrs ago

Des Moines (DSM)to

San Diego (SAN)
Depart: 09/25/2026

One-way

Basic

From
$193
Seen: 8 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Des Moines to San Diego

Aug 2026
From$464*
Seen: 8 hrs ago
One Way/Basic
Sep 2026
From$178*
Seen: 19 hrs ago
One Way/Basic
Oct 2026
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $178
cmp-daily-histogram-bars-legend-max-price-aria-label $549
Displaying fares for August-2026
  • DSM–SAN, 08/21/2026: From $549
    21

    Fri

    AUG

  • DSM–SAN, 08/22/2026: From $549
    22

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • DSM–SAN, 08/27/2026: From $464
    27

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • DSM–SAN, 08/29/2026: From $464
    29

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    31

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    SEP

  • DSM–SAN, 09/02/2026: From $464
    02

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • DSM–SAN, 09/05/2026: From $178
    05

    Sat

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • DSM–SAN, 09/08/2026: From $289
    08

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • DSM–SAN, 09/11/2026: From $178
    11

    Fri

  • DSM–SAN, 09/12/2026: From $178
    12

    Sat

  • DSM–SAN, 09/13/2026: From $338
    13

    Sun

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    14

    Mon

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    17

    Thu

  • DSM–SAN: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • DSM–SAN, 09/19/2026: From $178
    19

    Sat

  • DSM–SAN, 09/20/2026: From $338
    20

    Sun

    • Range$178-$549

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1428 miles

    Route Information

    76† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 76 weekly flights from Des Moines to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Des Moines to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Des Moines