Southwest® flights from Des Moines to St. Louis from $110

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Low fares from Des Moines to St. Louis

$

Des Moines (DSM)to

St. Louis (STL)
Depart: 09/06/2026

One-way

Basic

From
$110
Seen: 14 hrs ago

Des Moines (DSM)to

St. Louis (STL)
Depart: 08/26/2026

One-way

Basic

From
$123
Seen: 19 hrs ago

Des Moines (DSM)to

St. Louis (STL)
Depart: 09/15/2026

One-way

Basic

From
$123
Seen: 23 hrs ago

Des Moines (DSM)to

St. Louis (STL)
Depart: 10/01/2026

One-way

Basic

From
$123
Seen: 16 hrs ago

Des Moines (DSM)to

St. Louis (STL)
Depart: 08/25/2026

One-way

Basic

From
$123
Seen: 19 hrs ago

Des Moines (DSM)to

St. Louis (STL)
Depart: 09/06/2026

One-way

Choice

From
$145
Seen: 14 hrs ago

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Explore flights from Des Moines to St. Louis

Aug 2026
From$123*
Seen: 19 hrs ago
One Way/Basic
Sep 2026
From$110*
Seen: 14 hrs ago
One Way/Basic
Oct 2026
From$123*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $123
cmp-daily-histogram-bars-legend-max-price-aria-label $484
Displaying fares for August-2026
  • DSM–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Sun

    AUG

  • DSM–STL, 08/03/2026: From $484
    03

    Mon

  • DSM–STL, 08/04/2026: From $250
    04

    Tue

  • DSM–STL, 08/05/2026: From $350
    05

    Wed

  • DSM–STL, 08/06/2026: From $315
    06

    Thu

  • DSM–STL, 08/07/2026: From $285
    07

    Fri

  • DSM–STL, 08/08/2026: From $484
    08

    Sat

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    09

    Sun

  • DSM–STL, 08/10/2026: From $250
    10

    Mon

  • DSM–STL, 08/11/2026: From $250
    11

    Tue

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    12

    Wed

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    13

    Thu

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    14

    Fri

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    15

    Sat

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    16

    Sun

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    17

    Mon

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    18

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    19

    Wed

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    20

    Thu

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    21

    Fri

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    22

    Sat

  • DSM–STL, 08/23/2026: From $188
    23

    Sun

  • DSM–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • DSM–STL, 08/25/2026: From $123
    25

    Tue

  • DSM–STL, 08/26/2026: From $123
    26

    Wed

  • DSM–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Thu

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    28

    Fri

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    29

    Sat

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    30

    Sun

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    31

    Mon

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    01

    Tue

    SEP

    • Range$123-$484

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 10 minutes
    Distance:
    259 miles

    Route Information

    30† Weekly flights
    • 2‡ Nonstop flights per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Des Moines to St. Louis is 1 hour 10 minutes.
    There are 30 weekly flights from Des Moines to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Des Moines to St. Louis 2 times per day from Monday through Friday.
    Yes, Southwest flies nonstop from Des Moines to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly Des Moines to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Des Moines to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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