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Find low faresSouthwest® flights from Des Moines to Phoenix from $110
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Low fares from Des Moines to Phoenix
$
Des Moines (DSM)to
Phoenix (PHX)
Depart: 04/01/2026
One-way
Basic
From
$110
Seen: 12 hrs ago
Des Moines (DSM)to
Phoenix (PHX)
Depart: 03/07/2026
One-way
Basic
From
$111
Seen: 9 hrs ago
Des Moines (DSM)to
Phoenix (PHX)
Depart: 03/21/2026
One-way
Basic
From
$111
Seen: 11 hrs ago
Des Moines (DSM)to
Phoenix (PHX)
Depart: 03/28/2026
One-way
Basic
From
$111
Seen: 6 hrs ago
Des Moines (DSM)to
Phoenix (PHX)
Depart: 03/17/2026
One-way
Basic
From
$120
Seen: 11 hrs ago
Des Moines (DSM)to
Phoenix (PHX)
Depart: 04/11/2026
One-way
Basic
From
$121
Seen: 4 hrs ago
Explore flights from Des Moines to Phoenix
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Flight Details
Departing from:
Des Moines Airport
Arriving at:
Sky Harbor International Airport
Average flight time:
3 hours 4 minutes
Distance:
1150 miles
Route Information
82† Weekly flights
- 1‡ Nonstop flight per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 1‡ Nonstop flight on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Des Moines to Phoenix is 3 hours 4 minutes.
There are 82 weekly flights from Des Moines to Phoenix on Southwest Airlines.
Yes, Southwest flies nonstop from Des Moines to Phoenix once per day from Monday through Friday.
Yes, Southwest flies nonstop from Des Moines to Phoenix once per day on Saturdays and Sundays.
To find the lowest fares by day and time to fly Des Moines to Phoenix with Southwest, check out our Low Fare Calendar.
You can rent a car at Sky Harbor International Airport book yours with your flight.
Yes! Flights from Des Moines to Phoenix—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.