Southwest® flights from Des Moines to Phoenix from $163

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Low fares from Des Moines to Phoenix

$

Des Moines (DSM)to

Phoenix (PHX)
Depart: 04/24/2026

One-way

Basic

From
$163
Seen: 6 hrs ago

Des Moines (DSM)to

Phoenix (PHX)
Depart: 04/02/2026

One-way

Basic

From
$171
Seen: 21 hrs ago

Des Moines (DSM)to

Phoenix (PHX)
Depart: 05/04/2026

One-way

Basic

From
$171
Seen: 18 hrs ago

Des Moines (DSM)to

Phoenix (PHX)
Depart: 04/22/2026

One-way

Basic

From
$173
Seen: 21 hrs ago

Des Moines (DSM)to

Phoenix (PHX)
Depart: 06/09/2026

One-way

Basic

From
$173
Seen: 15 hrs ago

Des Moines (DSM)to

Phoenix (PHX)
Depart: 05/09/2026

One-way

Basic

From
$175
Seen: 7 hrs ago

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Explore flights from Des Moines to Phoenix

Mar 2026
From$209*
Seen: 2 hrs ago
One Way/Basic
Apr 2026
From$163*
Seen: 6 hrs ago
One Way/Basic
May 2026
From$171*
Seen: 18 hrs ago
One Way/Basic
$171
$334
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    • Range$171-$334

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Sky Harbor International Airport
    Average flight time:
    3 hours 4 minutes
    Distance:
    1150 miles

    Route Information

    82† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Des Moines to Phoenix is 3 hours 4 minutes.
    There are 82 weekly flights from Des Moines to Phoenix on Southwest Airlines.
    Yes, Southwest flies nonstop from Des Moines to Phoenix once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Des Moines to Phoenix once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Des Moines to Phoenix with Southwest, check out our Low Fare Calendar.
    You can rent a car at Sky Harbor International Airport book yours with your flight.
    Yes! Flights from Des Moines to Phoenix—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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