Southwest® flights from Des Moines to Detroit from $350

Promo Code

Low fares from Des Moines to Detroit

$

Des Moines (DSM)to

Detroit (DTW)
Depart: 10/25/2026

One-way

Basic

From
$350
Seen: 1 hour ago

Des Moines (DSM)to

Detroit (DTW)
Depart: 10/25/2026

One-way

Choice

From
$390
Seen: 1 hour ago

Des Moines (DSM)to

Detroit (DTW)
Depart: 10/25/2026

One-way

Choice Preferred

From
$460
Seen: 1 hour ago

Des Moines (DSM)to

Detroit (DTW)
Depart: 10/25/2026

One-way

Choice Extra

From
$505
Seen: 1 hour ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Des Moines to Detroit

Oct 2026
From$350*
Seen: 1 hour ago
One Way/Basic
Nov 2026
No result for this month.
Dec 2026
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $350
Displaying fares for October-2026
  • DSM–DTW, 10/25/2026: From $350
    25

    Sun

    OCT

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    26

    Mon

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    27

    Tue

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    29

    Thu

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    30

    Fri

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    04

    Wed

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    05

    Thu

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    06

    Fri

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    08

    Sun

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    10

    Tue

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    11

    Wed

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • DSM–DTW: cmp-view-offers-disclaimer. Find Offers
    24

    Tue

    • Range$350

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Wayne County Airport
    Distance:
    533 miles

    Questions we hear the most

    There are 40 weekly flights from Des Moines to Detroit on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Detroit with Southwest, check out our Low Fare Calendar.
    You can rent a car at Wayne County Airport book yours with your flight.
    Yes! Flights from Des Moines to Detroit—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Des Moines