Southwest® flights from Des Moines to Louisville

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Low fares from Des Moines to Louisville

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Des Moines (DSM)to

Louisville (SDF)
Depart: 06/22/2026

One-way

Basic

From
$244
Seen: 14 hrs ago

Des Moines (DSM)to

Louisville (SDF)
Depart: 06/22/2026

One-way

Choice

From
$274
Seen: 14 hrs ago

Des Moines (DSM)to

Louisville (SDF)
Depart: 06/22/2026

One-way

Choice Preferred

From
$344
Seen: 14 hrs ago

Des Moines (DSM)to

Louisville (SDF)
Depart: 06/22/2026

One-way

Choice Extra

From
$384
Seen: 14 hrs ago

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    • *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Louisville International Airport
    Distance:
    481 miles

    Route Information

    29† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 29 weekly flights from Des Moines to Louisville on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Louisville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Louisville International Airport book yours with your flight.
    Yes! Flights from Des Moines to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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