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Southwest® flights from Des Moines to Memphis from $161

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Low fares from Des Moines to Memphis

$

Des Moines (DSM)to

Memphis (MEM)
Depart: 08/08/2026

One-way

Basic

From
$161
Seen: 22 hrs ago

Des Moines (DSM)to

Memphis (MEM)
Depart: 06/18/2026

One-way

Basic

From
$174
Seen: 16 hrs ago

Des Moines (DSM)to

Memphis (MEM)
Depart: 08/08/2026

One-way

Choice

From
$196
Seen: 22 hrs ago

Des Moines (DSM)to

Memphis (MEM)
Depart: 06/18/2026

One-way

Choice

From
$209
Seen: 16 hrs ago

Des Moines (DSM)to

Memphis (MEM)
Depart: 08/08/2026

One-way

Choice Preferred

From
$266
Seen: 22 hrs ago

Des Moines (DSM)to

Memphis (MEM)
Depart: 06/18/2026

One-way

Choice Preferred

From
$279
Seen: 16 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

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Explore flights from Des Moines to Memphis

May 2026
From$340*
Seen: 1 hour ago
One Way/Basic
Jun 2026
From$174*
Seen: 16 hrs ago
One Way/Basic
Jul 2026
No result for this month.
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    • Range$340

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Memphis International Airport
    Distance:
    490 miles

    Route Information

    33† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 33 weekly flights from Des Moines to Memphis on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Memphis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Memphis International Airport book yours with your flight.
    Yes! Flights from Des Moines to Memphis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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