Southwest® flights from Knoxville to Chicago (O'Hare)

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Low fares from Knoxville to Chicago (O'Hare)

$

Low fares from Knoxville to Chicago (O'Hare)

$

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 11/11/2026

One-way

Basic

From
$122
Seen: 20 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 11/14/2026

One-way

Basic

From
$122
Seen: 16 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 11/10/2026

One-way

Basic

From
$122
Seen: 20 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 11/16/2026

One-way

Basic

From
$122
Seen: 16 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 10/05/2026

One-way

Basic

From
$122
Seen: 13 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 11/05/2026

One-way

Basic

From
$122
Seen: 1 hour ago

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Explore flights from Knoxville to Chicago (O'Hare)

Aug 2026
From$250*
Seen: 15 hrs ago
One Way/Basic
Sep 2026
From$132*
Seen: 4 hrs ago
One Way/Basic
Oct 2026
From$122*
Seen: 13 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $132
cmp-daily-histogram-bars-legend-max-price-aria-label $278
Displaying fares for August-2026
  • TYS–MDW, 08/27/2026: From $250
    27

    Thu

    AUG

  • TYS–MDW, 08/28/2026: From $250
    28

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    29

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • TYS–MDW, 08/31/2026: From $250
    31

    Mon

  • TYS–MDW, 09/01/2026: From $185
    01

    Tue

    SEP

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • TYS–MDW, 09/03/2026: From $200
    03

    Thu

  • TYS–MDW, 09/04/2026: From $195
    04

    Fri

  • TYS–MDW, 09/05/2026: From $175
    05

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • TYS–MDW, 09/08/2026: From $155
    08

    Tue

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • TYS–MDW, 09/10/2026: From $165
    10

    Thu

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • TYS–MDW, 09/12/2026: From $165
    12

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • TYS–MDW, 09/14/2026: From $165
    14

    Mon

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    17

    Thu

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • TYS–MDW, 09/20/2026: From $278
    20

    Sun

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • TYS–MDW, 09/25/2026: From $132
    25

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

    • Range$132-$278

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    O'Hare International Airport
    Distance:
    475 miles

    Route Information

    18† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 18 weekly flights from Knoxville to Chicago (O'Hare) on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Chicago (O'Hare) with Southwest, check out our Low Fare Calendar.
    You can rent a car at O'Hare International Airport book yours with your flight.
    Yes! Flights from Knoxville to Chicago (O'Hare)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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