Southwest® flights from Knoxville to New Orleans from $155

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Low fares from Knoxville to New Orleans

$

Knoxville (TYS)to

New Orleans (MSY)
Depart: 01/13/2027

One-way

Basic

From
$155

Low fares from Knoxville to New Orleans

$

Knoxville (TYS)to

New Orleans (MSY)
Depart: 01/13/2027

One-way

Basic

From
$155
Seen: 20 hrs ago

Knoxville (TYS)to

New Orleans (MSY)
Depart: 01/14/2027

One-way

Basic

From
$175
Seen: 21 hrs ago

Knoxville (TYS)to

New Orleans (MSY)
Depart: 12/17/2026

One-way

Basic

From
$180
Seen: 20 hrs ago

Knoxville (TYS)to

New Orleans (MSY)
Depart: 01/21/2027

One-way

Basic

From
$180
Seen: 15 hrs ago

Knoxville (TYS)to

New Orleans (MSY)
Depart: 12/11/2026

One-way

Basic

From
$180
Seen: 23 hrs ago

Knoxville (TYS)to

New Orleans (MSY)
Depart: 02/11/2027

One-way

Basic

From
$184
Seen: 20 hrs ago

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Explore flights from Knoxville to New Orleans

Nov 2026
From$249*
Seen: 17 hrs ago
One Way/Basic
Dec 2026
From$180*
Seen: 20 hrs ago
One Way/Basic
Jan 2027
From$155*
Seen: 20 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $249
cmp-daily-histogram-bars-legend-max-price-aria-label $394
Displaying fares for November-2026
  • TYS–MSY, 11/11/2026: From $265
    11

    Wed

    NOV

  • TYS–MSY, 11/12/2026: From $340
    12

    Thu

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • TYS–MSY, 11/14/2026: From $272
    14

    Sat

  • TYS–MSY, 11/15/2026: From $340
    15

    Sun

  • TYS–MSY, 11/16/2026: From $340
    16

    Mon

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • TYS–MSY, 11/18/2026: From $265
    18

    Wed

  • TYS–MSY, 11/19/2026: From $284
    19

    Thu

  • TYS–MSY, 11/20/2026: From $284
    20

    Fri

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • TYS–MSY, 11/22/2026: From $364
    22

    Sun

  • TYS–MSY, 11/23/2026: From $284
    23

    Mon

  • TYS–MSY, 11/24/2026: From $364
    24

    Tue

  • TYS–MSY, 11/25/2026: From $265
    25

    Wed

  • TYS–MSY, 11/26/2026: From $249
    26

    Thu

  • TYS–MSY, 11/27/2026: From $279
    27

    Fri

  • TYS–MSY, 11/28/2026: From $340
    28

    Sat

  • TYS–MSY, 11/29/2026: From $394
    29

    Sun

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    DEC

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    02

    Wed

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    03

    Thu

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    04

    Fri

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    05

    Sat

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    06

    Sun

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    07

    Mon

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    08

    Tue

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    09

    Wed

  • TYS–MSY: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

    • Range$249-$394

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Louis Armstrong International Airport
    Distance:
    541 miles

    Questions we hear the most

    There are 70 weekly flights from Knoxville to New Orleans on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to New Orleans with Southwest, check out our Low Fare Calendar.
    You can rent a car at Louis Armstrong International Airport book yours with your flight.
    Yes! Flights from Knoxville to New Orleans—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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