Southwest® flights from Knoxville to New Orleans from $139
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1 Passenger
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Low fares from Knoxville to New Orleans
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$
Knoxville (TYS)to
New Orleans (MSY)
Depart: 05/05/2026
One-way
Basic
From
$139
Low fares from Knoxville to New Orleans
$
Knoxville (TYS)to
New Orleans (MSY)
Depart: 05/05/2026
One-way
Basic
From
$139
Seen: 22 hrs ago
Knoxville (TYS)to
New Orleans (MSY)
Depart: 04/29/2026
One-way
Basic
From
$139
Seen: 19 hrs ago
Knoxville (TYS)to
New Orleans (MSY)
Depart: 03/16/2026
One-way
Basic
From
$149
Seen: 23 hrs ago
Knoxville (TYS)to
New Orleans (MSY)
Depart: 05/11/2026
One-way
Basic
From
$150
Seen: 9 hrs ago
Knoxville (TYS)to
New Orleans (MSY)
Depart: 04/21/2026
One-way
Basic
From
$150
Seen: 8 hrs ago
Knoxville (TYS)to
New Orleans (MSY)
Depart: 04/18/2026
One-way
Basic
From
$150
Seen: 5 hrs ago
Explore flights from Knoxville to New Orleans
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Flight Details
Departing from:
Mc Ghee Tyson Airport
Arriving at:
Louis Armstrong International Airport
Distance:
541 miles
Route Information
70† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 70 weekly flights from Knoxville to New Orleans on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to New Orleans with Southwest, check out our Low Fare Calendar.
You can rent a car at Louis Armstrong International Airport book yours with your flight.
Yes! Flights from Knoxville to New Orleans—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.