Southwest® flights from Knoxville to St. Louis from $106

Promo Code

Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 08/29/2026

One-way

Basic

From
$106

Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 08/25/2026

One-way

Basic

From
$106
Seen: 10 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 08/29/2026

One-way

Basic

From
$106
Seen: 10 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 08/19/2026

One-way

Basic

From
$106
Seen: 17 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 10/17/2026

One-way

Basic

From
$106
Seen: 15 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 08/18/2026

One-way

Basic

From
$111
Seen: 18 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 09/11/2026

One-way

Basic

From
$111
Seen: 18 hrs ago

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Explore flights from Knoxville to St. Louis

Jul 2026
From$325*
Seen: 3 hrs ago
One Way/Basic
Aug 2026
From$106*
Seen: 17 hrs ago
One Way/Basic
Sep 2026
From$111*
Seen: 18 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $106
cmp-daily-histogram-bars-legend-max-price-aria-label $369
Displaying fares for July-2026
  • TYS–STL, 07/31/2026: From $325
    31

    Fri

    JUL

  • TYS–STL, 08/01/2026: From $261
    01

    Sat

  • TYS–STL, 08/02/2026: From $369
    02

    Sun

  • TYS–STL, 08/03/2026: From $325
    03

    Mon

  • TYS–STL, 08/04/2026: From $295
    04

    Tue

  • TYS–STL, 08/05/2026: From $261
    05

    Wed

  • TYS–STL, 08/06/2026: From $319
    06

    Thu

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    07

    Fri

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    08

    Sat

  • TYS–STL, 08/09/2026: From $335
    09

    Sun

  • TYS–STL, 08/10/2026: From $319
    10

    Mon

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    11

    Tue

  • TYS–STL, 08/12/2026: From $224
    12

    Wed

  • TYS–STL, 08/13/2026: From $224
    13

    Thu

  • TYS–STL, 08/14/2026: From $224
    14

    Fri

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Sat

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    16

    Sun

  • TYS–STL, 08/17/2026: From $224
    17

    Mon

  • TYS–STL, 08/18/2026: From $111
    18

    Tue

  • TYS–STL, 08/19/2026: From $106
    19

    Wed

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    20

    Thu

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    21

    Fri

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    22

    Sat

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • TYS–STL, 08/25/2026: From $106
    25

    Tue

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Thu

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • TYS–STL, 08/29/2026: From $106
    29

    Sat

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

    • Range$106-$369

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Distance:
    405 miles

    Route Information

    61† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 61 weekly flights from Knoxville to St. Louis on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Knoxville to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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