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Southwest® flights from Knoxville to St. Louis from $135

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Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/16/2026

One-way

Basic

From
$135

Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/09/2026

One-way

Basic

From
$135
Seen: 18 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/16/2026

One-way

Basic

From
$135
Seen: 22 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/06/2026

One-way

Basic

From
$145
Seen: 12 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/04/2026

One-way

Basic

From
$145
Seen: 1 hour ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/20/2026

One-way

Basic

From
$150
Seen: 20 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 06/18/2026

One-way

Basic

From
$150
Seen: 17 hrs ago

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Explore flights from Knoxville to St. Louis

May 2026
From$150*
Seen: 3 hrs ago
One Way/Basic
Jun 2026
From$135*
Seen: 18 hrs ago
One Way/Basic
Jul 2026
From$150*
Seen: 33 minutes ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $135
cmp-daily-histogram-bars-legend-max-price-aria-label $314
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    • Range$135-$314

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Distance:
    405 miles

    Route Information

    61† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 61 weekly flights from Knoxville to St. Louis on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Knoxville to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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