Southwest® flights from Knoxville to St. Louis from $117
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1 Passenger
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Low fares from Knoxville to St. Louis
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$
Knoxville (TYS)to
St. Louis (STL)
Depart: 03/31/2026
One-way
Basic
From
$117
Low fares from Knoxville to St. Louis
$
Knoxville (TYS)to
St. Louis (STL)
Depart: 04/07/2026
One-way
Basic
From
$117
Seen: 13 hrs ago
Knoxville (TYS)to
St. Louis (STL)
Depart: 03/31/2026
One-way
Basic
From
$117
Seen: 16 hrs ago
Knoxville (TYS)to
St. Louis (STL)
Depart: 04/01/2026
One-way
Basic
From
$117
Seen: 8 hrs ago
Knoxville (TYS)to
St. Louis (STL)
Depart: 05/09/2026
One-way
Basic
From
$118
Seen: 7 hrs ago
Knoxville (TYS)to
St. Louis (STL)
Depart: 03/23/2026
One-way
Basic
From
$118
Seen: 7 hrs ago
Knoxville (TYS)to
St. Louis (STL)
Depart: 03/19/2026
One-way
Basic
From
$140
Seen: 16 hrs ago
Explore flights from Knoxville to St. Louis
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Flight Details
Departing from:
Mc Ghee Tyson Airport
Arriving at:
Lambert-St Louis Int'l Airport
Distance:
405 miles
Route Information
61† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 61 weekly flights from Knoxville to St. Louis on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Knoxville to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.