Southwest® flights from Knoxville to St. Louis from $134

Promo Code

Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/01/2026

One-way

Basic

From
$134

Low fares from Knoxville to St. Louis

$

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/01/2026

One-way

Basic

From
$134
Seen: 21 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/03/2026

One-way

Basic

From
$159
Seen: 21 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/10/2026

One-way

Basic

From
$159
Seen: 6 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/01/2026

One-way

Choice

From
$169
Seen: 21 hrs ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 01/15/2027

One-way

Basic

From
$170
Seen: 1 hour ago

Knoxville (TYS)to

St. Louis (STL)
Depart: 12/23/2026

One-way

Basic

From
$174
Seen: 9 hrs ago

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Explore flights from Knoxville to St. Louis

Nov 2026
From$249*
Seen: 13 hrs ago
One Way/Basic
Dec 2026
From$134*
Seen: 21 hrs ago
One Way/Basic
Jan 2027
From$170*
Seen: 1 hour ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $134
cmp-daily-histogram-bars-legend-max-price-aria-label $399
Displaying fares for November-2026
  • TYS–STL, 11/11/2026: From $286
    11

    Wed

    NOV

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • TYS–STL, 11/13/2026: From $350
    13

    Fri

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    14

    Sat

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    15

    Sun

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    16

    Mon

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    17

    Tue

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    18

    Wed

  • TYS–STL, 11/19/2026: From $344
    19

    Thu

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • TYS–STL, 11/22/2026: From $369
    22

    Sun

  • TYS–STL, 11/23/2026: From $249
    23

    Mon

  • TYS–STL, 11/24/2026: From $369
    24

    Tue

  • TYS–STL, 11/25/2026: From $249
    25

    Wed

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • TYS–STL, 11/27/2026: From $259
    27

    Fri

  • TYS–STL, 11/28/2026: From $353
    28

    Sat

  • TYS–STL, 11/29/2026: From $399
    29

    Sun

  • TYS–STL, 11/30/2026: From $309
    30

    Mon

  • TYS–STL, 12/01/2026: From $134
    01

    Tue

    DEC

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • TYS–STL, 12/03/2026: From $159
    03

    Thu

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

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    05

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    06

    Sun

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    07

    Mon

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    08

    Tue

  • TYS–STL: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • TYS–STL, 12/10/2026: From $159
    10

    Thu

    • Range$134-$399

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Distance:
    405 miles

    Questions we hear the most

    There are 61 weekly flights from Knoxville to St. Louis on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Knoxville to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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