Southwest® flights from Des Moines to Knoxville from $161

Promo Code

Low fares from Des Moines to Knoxville

$

Des Moines (DSM)to

Knoxville (TYS)
Depart: 05/13/2026

One-way

Basic

From
$161

Low fares from Des Moines to Knoxville

$

Des Moines (DSM)to

Knoxville (TYS)
Depart: 05/13/2026

One-way

Basic

From
$161
Seen: 2 hrs ago

Des Moines (DSM)to

Knoxville (TYS)
Depart: 04/12/2026

One-way

Basic

From
$185
Seen: 23 hrs ago

Des Moines (DSM)to

Knoxville (TYS)
Depart: 05/13/2026

One-way

Choice

From
$196
Seen: 2 hrs ago

Des Moines (DSM)to

Knoxville (TYS)
Depart: 06/17/2026

One-way

Basic

From
$204
Seen: 19 hrs ago

Des Moines (DSM)to

Knoxville (TYS)
Depart: 04/12/2026

One-way

Choice

From
$220
Seen: 23 hrs ago

Des Moines (DSM)to

Knoxville (TYS)
Depart: 06/17/2026

One-way

Choice

From
$239
Seen: 19 hrs ago

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Explore flights from Des Moines to Knoxville

Try alternate month or interact with individual days below in order to find offers.
Mar 2026
No result for this month.
Apr 2026
From$185*
Seen: 23 hrs ago
One Way/Basic
May 2026
From$161*
Seen: 2 hrs ago
One Way/Basic
$185
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    • Range$185-$245

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    654 miles

    Route Information

    27† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 27 weekly flights from Des Moines to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Des Moines to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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