Southwest® flights from Des Moines to Santa Rosa from $220

Promo Code

Low fares from Des Moines to Santa Rosa

$

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 05/23/2026

One-way

Basic

From
$220

Low fares from Des Moines to Santa Rosa

$

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 05/23/2026

One-way

Basic

From
$220
Seen: 2 hrs ago

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 05/23/2026

One-way

Choice

From
$265
Seen: 2 hrs ago

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 05/23/2026

One-way

Choice Preferred

From
$345
Seen: 2 hrs ago

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 05/23/2026

One-way

Choice Extra

From
$405
Seen: 2 hrs ago

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 04/25/2026

One-way

Choice

From
$455
Seen: 2 hrs ago

Des Moines (DSM)to

Santa Rosa (STS)
Depart: 04/25/2026

One-way

Choice Preferred

From
$535
Seen: 2 hrs ago

Looking for more low-fare flights?

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Explore flights from Des Moines to Santa Rosa

Apr 2026
From$455*
Seen: 2 hrs ago
One Way/Basic
May 2026
From$220*
Seen: 2 hrs ago
One Way/Basic
Jun 2026
No result for this month.
$455
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    • Range$455

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Charles M. Schulz–Sonoma County Airport
    Distance:
    1553 miles

    Route Information

    20† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 20 weekly flights from Des Moines to Santa Rosa on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Santa Rosa with Southwest, check out our Low Fare Calendar.
    You can rent a car at Charles M. Schulz–Sonoma County Airport book yours with your flight.
    Yes! Flights from Des Moines to Santa Rosa—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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