Southwest® flights from Knoxville to Chicago-Midway from $130

Promo Code

Low fares from Knoxville to Chicago-Midway

$

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 11/02/2026

One-way

Basic

From
$130

Low fares from Knoxville to Chicago-Midway

$

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 11/02/2026

One-way

Basic

From
$130
Seen: 20 hrs ago

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 10/22/2026

One-way

Basic

From
$130
Seen: 19 hrs ago

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 10/20/2026

One-way

Basic

From
$130
Seen: 18 hrs ago

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 11/16/2026

One-way

Basic

From
$130
Seen: 15 hrs ago

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 10/28/2026

One-way

Basic

From
$130
Seen: 5 hrs ago

Knoxville (TYS)to

Chicago-Midway (MDW)
Depart: 10/09/2026

One-way

Basic

From
$140
Seen: 10 hrs ago

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Explore flights from Knoxville to Chicago-Midway

Sep 2026
From$170*
Seen: 11 hrs ago
One Way/Basic
Oct 2026
From$130*
Seen: 19 hrs ago
One Way/Basic
Nov 2026
From$130*
Seen: 15 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $140
cmp-daily-histogram-bars-legend-max-price-aria-label $401
Displaying fares for September-2026
  • TYS–MDW, 09/10/2026: From $285
    10

    Thu

    SEP

  • TYS–MDW, 09/11/2026: From $250
    11

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • TYS–MDW, 09/13/2026: From $255
    13

    Sun

  • TYS–MDW, 09/14/2026: From $250
    14

    Mon

  • TYS–MDW, 09/15/2026: From $195
    15

    Tue

  • TYS–MDW, 09/16/2026: From $195
    16

    Wed

  • TYS–MDW, 09/17/2026: From $195
    17

    Thu

  • TYS–MDW, 09/18/2026: From $195
    18

    Fri

  • TYS–MDW, 09/19/2026: From $195
    19

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

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    23

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

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    25

    Fri

  • TYS–MDW, 09/26/2026: From $170
    26

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • TYS–MDW, 09/28/2026: From $240
    28

    Mon

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

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    30

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    01

    Thu

    OCT

  • TYS–MDW, 10/02/2026: From $279
    02

    Fri

  • TYS–MDW, 10/03/2026: From $279
    03

    Sat

  • TYS–MDW, 10/04/2026: From $401
    04

    Sun

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    05

    Mon

  • TYS–MDW, 10/06/2026: From $185
    06

    Tue

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    07

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    08

    Thu

  • TYS–MDW, 10/09/2026: From $140
    09

    Fri

    • Range$140-$401

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Chicago Midway International Airport
    Distance:
    459 miles

    Route Information

    74† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 74 weekly flights from Knoxville to Chicago (Midway) on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Chicago (Midway) with Southwest, check out our Low Fare Calendar.
    You can rent a car at Chicago Midway International Airport book yours with your flight.
    Yes! Flights from Knoxville to Chicago (Midway)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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