Southwest® flights from Knoxville to Chicago (Midway) from $122

Promo Code

Low fares from Knoxville to Chicago (Midway)

$

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/24/2026

One-way

Basic

From
$122

Low fares from Knoxville to Chicago (Midway)

$

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/24/2026

One-way

Basic

From
$122
Seen: 10 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/19/2026

One-way

Basic

From
$122
Seen: 6 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/17/2026

One-way

Basic

From
$122
Seen: 18 minutes ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/23/2026

One-way

Basic

From
$122
Seen: 20 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/22/2026

One-way

Basic

From
$122
Seen: 15 hrs ago

Knoxville (TYS)to

Chicago (Midway) (MDW)
Depart: 09/15/2026

One-way

Basic

From
$122
Seen: 10 hrs ago

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Explore flights from Knoxville to Chicago (Midway)

Aug 2026
From$200*
Seen: 21 hrs ago
One Way/Basic
Sep 2026
From$122*
Seen: 20 hrs ago
One Way/Basic
Oct 2026
From$127*
Seen: 13 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $122
cmp-daily-histogram-bars-legend-max-price-aria-label $334
Displaying fares for August-2026
  • TYS–MDW, 08/21/2026: From $240
    21

    Fri

    AUG

  • TYS–MDW, 08/22/2026: From $200
    22

    Sat

  • TYS–MDW, 08/23/2026: From $240
    23

    Sun

  • TYS–MDW, 08/24/2026: From $240
    24

    Mon

  • TYS–MDW, 08/25/2026: From $200
    25

    Tue

  • TYS–MDW, 08/26/2026: From $200
    26

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    27

    Thu

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    29

    Sat

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    31

    Mon

  • TYS–MDW, 09/01/2026: From $185
    01

    Tue

    SEP

  • TYS–MDW, 09/02/2026: From $185
    02

    Wed

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • TYS–MDW, 09/04/2026: From $155
    04

    Fri

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    05

    Sat

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    06

    Sun

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    07

    Mon

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • TYS–MDW, 09/10/2026: From $122
    10

    Thu

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • TYS–MDW, 09/13/2026: From $215
    13

    Sun

  • TYS–MDW, 09/14/2026: From $184
    14

    Mon

  • TYS–MDW, 09/15/2026: From $122
    15

    Tue

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • TYS–MDW, 09/17/2026: From $122
    17

    Thu

  • TYS–MDW: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • TYS–MDW, 09/19/2026: From $122
    19

    Sat

  • TYS–MDW, 09/20/2026: From $334
    20

    Sun

    • Range$122-$334

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Chicago Midway International Airport
    Distance:
    459 miles

    Route Information

    74† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 74 weekly flights from Knoxville to Chicago (Midway) on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Chicago (Midway) with Southwest, check out our Low Fare Calendar.
    You can rent a car at Chicago Midway International Airport book yours with your flight.
    Yes! Flights from Knoxville to Chicago (Midway)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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