Southwest® flights from Knoxville to San Francisco from $189

Promo Code

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 11/14/2026

One-way

Basic

From
$189

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 11/14/2026

One-way

Basic

From
$189
Seen: 18 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/03/2026

One-way

Basic

From
$189
Seen: 15 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 10/17/2026

One-way

Basic

From
$220
Seen: 18 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 10/23/2026

One-way

Basic

From
$230
Seen: 11 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 11/14/2026

One-way

Choice

From
$244
Seen: 18 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/03/2026

One-way

Choice

From
$244
Seen: 15 hrs ago

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Explore flights from Knoxville to San Francisco

Sep 2026
From$294*
Seen: 15 hrs ago
One Way/Basic
Oct 2026
From$220*
Seen: 18 hrs ago
One Way/Basic
Nov 2026
From$189*
Seen: 18 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $220
Displaying fares for September-2026
  • TYS–SFO, 09/29/2026: From $294
    29

    Tue

    SEP

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • TYS–SFO, 10/01/2026: From $374
    01

    Thu

    OCT

  • TYS–SFO, 10/02/2026: From $534
    02

    Fri

  • TYS–SFO, 10/03/2026: From $289
    03

    Sat

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    04

    Sun

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    05

    Mon

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    06

    Tue

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    07

    Wed

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    08

    Thu

  • TYS–SFO, 10/09/2026: From $374
    09

    Fri

  • TYS–SFO, 10/10/2026: From $289
    10

    Sat

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

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    12

    Mon

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    13

    Tue

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    14

    Wed

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    15

    Thu

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    16

    Fri

  • TYS–SFO, 10/17/2026: From $220
    17

    Sat

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    18

    Sun

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

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    20

    Tue

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    22

    Thu

  • TYS–SFO, 10/23/2026: From $230
    23

    Fri

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    24

    Sat

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    25

    Sun

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    26

    Mon

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    27

    Tue

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

    • Range$220-$534

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    2120 miles

    Route Information

    32† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 32 weekly flights from Knoxville to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Knoxville to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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