Southwest® flights from Knoxville to San Francisco from $170

Promo Code

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 03/10/2026

One-way

Basic

From
$170

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 03/10/2026

One-way

Basic

From
$170
Seen: 23 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 03/10/2026

One-way

Choice

From
$210
Seen: 23 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 04/28/2026

One-way

Basic

From
$253
Seen: 17 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 03/19/2026

One-way

Basic

From
$265
Seen: 1 hour ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 03/07/2026

One-way

Basic

From
$271
Seen: 23 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 04/17/2026

One-way

Basic

From
$284
Seen: 21 hrs ago

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Explore flights from Knoxville to San Francisco

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Mc Ghee Tyson Airport
Arriving at:
San Francisco International Airport
Distance:
2120 miles

Route Information

32† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 32 weekly flights from Knoxville to San Francisco on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to San Francisco with Southwest, check out our Low Fare Calendar.
You can rent a car at San Francisco International Airport book yours with your flight.
Yes! Flights from Knoxville to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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