Southwest® flights from Knoxville to San Francisco from $205

Promo Code

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 01/05/2027

One-way

Basic

From
$205

Low fares from Knoxville to San Francisco

$

Knoxville (TYS)to

San Francisco (SFO)
Depart: 01/05/2027

One-way

Basic

From
$205
Seen: 12 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/05/2026

One-way

Basic

From
$205
Seen: 6 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/02/2026

One-way

Basic

From
$205
Seen: 45 minutes ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/16/2026

One-way

Basic

From
$205
Seen: 19 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/09/2026

One-way

Basic

From
$205
Seen: 5 hrs ago

Knoxville (TYS)to

San Francisco (SFO)
Depart: 12/08/2026

One-way

Basic

From
$205
Seen: 36 minutes ago

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Explore flights from Knoxville to San Francisco

Nov 2026
From$300*
Seen: 22 hrs ago
One Way/Basic
Dec 2026
From$205*
Seen: 6 hrs ago
One Way/Basic
Jan 2027
From$205*
Seen: 12 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $205
cmp-daily-histogram-bars-legend-max-price-aria-label $786
Displaying fares for November-2026
  • TYS–SFO, 11/12/2026: From $442
    12

    Thu

    NOV

  • TYS–SFO, 11/13/2026: From $442
    13

    Fri

  • TYS–SFO, 11/14/2026: From $304
    14

    Sat

  • TYS–SFO, 11/15/2026: From $442
    15

    Sun

  • TYS–SFO, 11/16/2026: From $442
    16

    Mon

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • TYS–SFO, 11/18/2026: From $304
    18

    Wed

  • TYS–SFO, 11/19/2026: From $424
    19

    Thu

  • TYS–SFO, 11/20/2026: From $424
    20

    Fri

  • TYS–SFO, 11/21/2026: From $304
    21

    Sat

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • TYS–SFO, 11/23/2026: From $424
    23

    Mon

  • TYS–SFO, 11/24/2026: From $330
    24

    Tue

  • TYS–SFO, 11/25/2026: From $300
    25

    Wed

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • TYS–SFO, 11/29/2026: From $786
    29

    Sun

  • TYS–SFO: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • TYS–SFO, 12/01/2026: From $300
    01

    Tue

    DEC

  • TYS–SFO, 12/02/2026: From $205
    02

    Wed

  • TYS–SFO, 12/03/2026: From $225
    03

    Thu

  • TYS–SFO, 12/04/2026: From $240
    04

    Fri

  • TYS–SFO, 12/05/2026: From $205
    05

    Sat

  • TYS–SFO, 12/06/2026: From $279
    06

    Sun

  • TYS–SFO, 12/07/2026: From $230
    07

    Mon

  • TYS–SFO, 12/08/2026: From $205
    08

    Tue

  • TYS–SFO, 12/09/2026: From $205
    09

    Wed

  • TYS–SFO, 12/10/2026: From $225
    10

    Thu

  • TYS–SFO, 12/11/2026: From $240
    11

    Fri

    • Range$205-$786

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    San Francisco International Airport
    Distance:
    2120 miles

    Questions we hear the most

    There are 32 weekly flights from Knoxville to San Francisco on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to San Francisco with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Francisco International Airport book yours with your flight.
    Yes! Flights from Knoxville to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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