Spirit Airlines Customers: Southwest has options for Customers holding Spirit reservations. We’re here to help you continue your journey. Learn more.

Southwest® flights from Knoxville to Louisville from $169

Promo Code

Low fares from Knoxville to Louisville

$

Knoxville (TYS)to

Louisville (SDF)
Depart: 07/19/2026

One-way

Basic

From
$169

Low fares from Knoxville to Louisville

$

Knoxville (TYS)to

Louisville (SDF)
Depart: 07/19/2026

One-way

Basic

From
$169
Seen: 1 hour ago

Knoxville (TYS)to

Louisville (SDF)
Depart: 07/19/2026

One-way

Choice

From
$204
Seen: 1 hour ago

Knoxville (TYS)to

Louisville (SDF)
Depart: 07/19/2026

One-way

Choice Preferred

From
$274
Seen: 1 hour ago

Knoxville (TYS)to

Louisville (SDF)
Depart: 05/13/2026

One-way

Choice

From
$288
Seen: 7 hrs ago

Knoxville (TYS)to

Louisville (SDF)
Depart: 07/19/2026

One-way

Choice Extra

From
$314
Seen: 1 hour ago

Knoxville (TYS)to

Louisville (SDF)
Depart: 05/14/2026

One-way

Choice

From
$314
Seen: 7 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Knoxville to Louisville

May 2026
From$288*
Seen: 7 hrs ago
One Way/Basic
Jun 2026
No result for this month.
Jul 2026
From$169*
Seen: 1 hour ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $288
Displaying fares for May-2026
  • 12

    Tue

    MAY

  • 13

    Wed

  • 14

    Thu

  • 15

    Fri

  • 16

    Sat

  • 17

    Sun

  • 18

    Mon

  • 19

    Tue

  • 20

    Wed

  • 21

    Thu

  • 22

    Fri

  • 23

    Sat

  • 24

    Sun

  • 25

    Mon

  • 26

    Tue

  • 27

    Wed

  • 28

    Thu

  • 29

    Fri

  • 30

    Sat

  • 31

    Sun

  • 01

    Mon

    JUN

  • 02

    Tue

  • 03

    Wed

  • 04

    Thu

  • 05

    Fri

  • 06

    Sat

  • 07

    Sun

  • 08

    Mon

  • 09

    Tue

  • 10

    Wed

  • 11

    Thu

    • Range$288-$314

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Louisville International Airport
    Distance:
    189 miles

    Route Information

    25† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 25 weekly flights from Knoxville to Louisville on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Louisville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Louisville International Airport book yours with your flight.
    Yes! Flights from Knoxville to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Knoxville