Southwest® flights from Knoxville to Fort Myers/Naples from $130

Promo Code

Low fares from Knoxville to Fort Myers/Naples

$

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 04/01/2026

One-way

Basic

From
$130

Low fares from Knoxville to Fort Myers/Naples

$

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 04/01/2026

One-way

Basic

From
$130
Seen: 8 hrs ago

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 03/11/2026

One-way

Basic

From
$150
Seen: 45 minutes ago

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 04/01/2026

One-way

Choice

From
$165
Seen: 8 hrs ago

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 04/16/2026

One-way

Basic

From
$184
Seen: 9 hrs ago

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 03/11/2026

One-way

Choice

From
$185
Seen: 45 minutes ago

Knoxville (TYS)to

Fort Myers/Naples (RSW)
Depart: 04/02/2026

One-way

Basic

From
$194
Seen: 8 hrs ago

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Explore flights from Knoxville to Fort Myers/Naples

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Mc Ghee Tyson Airport
Arriving at:
Southwest Florida Regional Airport
Distance:
653 miles

Route Information

45† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 45 weekly flights from Knoxville to Fort Myers/Naples on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to Fort Myers/Naples with Southwest, check out our Low Fare Calendar.
You can rent a car at Southwest Florida Regional Airport book yours with your flight.
Yes! Flights from Knoxville to Fort Myers/Naples—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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