Southwest® flights from Knoxville to Panama City Beach, FL from $117

Promo Code

Low fares from Knoxville to Panama City Beach, FL

$

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 03/18/2026

One-way

Basic

From
$117

Low fares from Knoxville to Panama City Beach, FL

$

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 03/18/2026

One-way

Basic

From
$117
Seen: 23 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 04/07/2026

One-way

Basic

From
$118
Seen: 5 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 05/10/2026

One-way

Basic

From
$140
Seen: 7 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 03/18/2026

One-way

Choice

From
$147
Seen: 23 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 04/07/2026

One-way

Choice

From
$148
Seen: 5 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 03/14/2026

One-way

Basic

From
$155
Seen: 7 hrs ago

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Explore flights from Knoxville to Panama City Beach, FL

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Mc Ghee Tyson Airport
Arriving at:
Northwest Florida Beaches International Airport
Distance:
390 miles

Route Information

44† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 44 weekly flights from Knoxville to Panama City Beach, FL on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to Panama City Beach, FL with Southwest, check out our Low Fare Calendar.
You can rent a car at Northwest Florida Beaches International Airport book yours with your flight.
Yes! Flights from Knoxville to Panama City Beach, FL—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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