Southwest® flights from Knoxville to Panama City Beach, FL from $204

Promo Code

Low fares from Knoxville to Panama City Beach, FL

$

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/20/2026

One-way

Basic

From
$204

Low fares from Knoxville to Panama City Beach, FL

$

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/20/2026

One-way

Basic

From
$204
Seen: 1 hour ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/20/2026

One-way

Choice

From
$239
Seen: 1 hour ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/22/2026

One-way

Basic

From
$279
Seen: 5 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/20/2026

One-way

Choice Preferred

From
$309
Seen: 1 hour ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/22/2026

One-way

Choice

From
$314
Seen: 5 hrs ago

Knoxville (TYS)to

Panama City Beach, FL (ECP)
Depart: 10/20/2026

One-way

Choice Extra

From
$349
Seen: 1 hour ago

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Explore flights from Knoxville to Panama City Beach, FL

Sep 2026
From$354*
Seen: 7 hrs ago
One Way/Basic
Oct 2026
From$204*
Seen: 1 hour ago
One Way/Basic
Nov 2026
From$354*
Seen: 23 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $204
Displaying fares for September-2026
  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

    SEP

  • TYS–ECP, 09/22/2026: From $354
    22

    Tue

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    23

    Wed

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    24

    Thu

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    25

    Fri

  • TYS–ECP, 09/26/2026: From $354
    26

    Sat

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    27

    Sun

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    28

    Mon

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    29

    Tue

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    30

    Wed

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    01

    Thu

    OCT

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    02

    Fri

  • TYS–ECP, 10/03/2026: From $504
    03

    Sat

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    04

    Sun

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    05

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    06

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    07

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    08

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    09

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    10

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  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    12

    Mon

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    13

    Tue

  • TYS–ECP, 10/14/2026: From $359
    14

    Wed

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    15

    Thu

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    16

    Fri

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    17

    Sat

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    18

    Sun

  • TYS–ECP: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

  • TYS–ECP, 10/20/2026: From $204
    20

    Tue

    • Range$204-$504

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Northwest Florida Beaches International Airport
    Distance:
    390 miles

    Route Information

    44† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 44 weekly flights from Knoxville to Panama City Beach, FL on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Panama City Beach, FL with Southwest, check out our Low Fare Calendar.
    You can rent a car at Northwest Florida Beaches International Airport book yours with your flight.
    Yes! Flights from Knoxville to Panama City Beach, FL—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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