Southwest® flights to Knoxville starting at $59

Promo Code

Popular flights to Knoxville on Southwest Airlines

$

Nashville (BNA)to

Knoxville (TYS)
Depart: 11/26/2026
From
$59
One-way
Basic

Houston Hobby (HOU)to

Knoxville (TYS)
Depart: 12/04/2026
From
$60
One-way
Basic

Baltimore/Washington (BWI)to

Knoxville (TYS)
Depart: 12/02/2026
From
$93
One-way
Basic

Washington D.C. Reagan National (DCA)to

Knoxville (TYS)
Depart: 11/26/2026
From
$96
One-way
Basic

Dallas-Love Field (DAL)to

Knoxville (TYS)
Depart: 12/05/2026
From
$110
One-way
Basic

Hartford/Springfield (BDL)to

Knoxville (TYS)
Depart: 01/21/2027
From
$115
One-way
Basic

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 12/05/2026
From
$115
One-way
Basic

Fort Lauderdale (FLL)to

Knoxville (TYS)
Depart: 12/02/2026
From
$115
One-way
Basic

Jacksonville (JAX)to

Knoxville (TYS)
Depart: 12/19/2026
From
$115
One-way
Basic

El Paso (ELP)to

Knoxville (TYS)
Depart: 01/28/2027
From
$119
One-way
Basic

Boston (BOS)to

Knoxville (TYS)
Depart: 11/16/2026
From
$120
One-way
Basic

Cleveland (CLE)to

Knoxville (TYS)
Depart: 11/18/2026
From
$120
One-way
Basic

Columbus (CMH)to

Knoxville (TYS)
Depart: 11/14/2026
From
$120
One-way
Basic

Indianapolis (IND)to

Knoxville (TYS)
Depart: 11/17/2026
From
$120
One-way
Basic

Austin (AUS)to

Knoxville (TYS)
Depart: 11/17/2026
From
$122
One-way
Basic

Cincinnati (CVG)to

Knoxville (TYS)
Depart: 12/11/2026
From
$123
One-way
Basic

Lubbock (LBB)to

Knoxville (TYS)
Depart: 11/10/2026
From
$123
One-way
Basic

Birmingham (BHM)to

Knoxville (TYS)
Depart: 12/14/2026
From
$126
One-way
Basic

Buffalo/Niagara Falls (BUF)to

Knoxville (TYS)
Depart: 11/16/2026
From
$126
One-way
Basic

Charleston (CHS)to

Knoxville (TYS)
Depart: 12/17/2026
From
$126
One-way
Basic
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Popular flights to Knoxville on Southwest Airlines

$

Nashville (BNA)to

Knoxville (TYS)
Depart: 11/14/2026
From
$59
Seen: 4 hrs ago
One-way
Basic

Baltimore/Washington (BWI)to

Knoxville (TYS)
Depart: 11/16/2026
From
$99
Seen: 14 hrs ago
One-way
Basic

Hartford/Springfield (BDL)to

Knoxville (TYS)
Depart: 11/09/2026
From
$115
Seen: 6 hrs ago
One-way
Basic

Boston (BOS)to

Knoxville (TYS)
Depart: 11/18/2026
From
$120
Seen: 17 hrs ago
One-way
Basic

Cleveland (CLE)to

Knoxville (TYS)
Depart: 11/18/2026
From
$120
Seen: 50 minutes ago
One-way
Basic

Columbus (CMH)to

Knoxville (TYS)
Depart: 11/18/2026
From
$120
Seen: 16 hrs ago
One-way
Basic

Austin (AUS)to

Knoxville (TYS)
Depart: 11/17/2026
From
$122
Seen: 8 hrs ago
One-way
Basic

Buffalo/Niagara Falls (BUF)to

Knoxville (TYS)
Depart: 11/14/2026
From
$126
Seen: 19 hrs ago
One-way
Basic

Charleston (CHS)to

Knoxville (TYS)
Depart: 11/18/2026
From
$126
Seen: 19 hrs ago
One-way
Basic

Albany (ALB)to

Knoxville (TYS)
Depart: 11/09/2026
From
$132
Seen: 12 hrs ago
One-way
Basic

Albuquerque (ABQ)to

Knoxville (TYS)
Depart: 11/10/2026
From
$144
Seen: 8 hrs ago
One-way
Basic

Charlotte (CLT)to

Knoxville (TYS)
Depart: 11/14/2026
From
$144
Seen: 11 hrs ago
One-way
Basic

Boise (BOI)to

Knoxville (TYS)
Depart: 11/18/2026
From
$180
Seen: 12 hrs ago
One-way
Basic

Burbank (BUR)to

Knoxville (TYS)
Depart: 11/10/2026
From
$197
Seen: 15 hrs ago
One-way
Basic

Atlanta (ATL)to

Knoxville (TYS)
Depart: 10/27/2026
From
$199
Seen: 11 hrs ago
One-way
Basic

Birmingham (BHM)to

Knoxville (TYS)
Depart: 11/05/2026
From
$244
Seen: 23 hrs ago
One-way
Basic

Bozeman (BZN)to

Knoxville (TYS)
Depart: 10/24/2026
From
$245
Seen: 22 hrs ago
One-way
Basic

Amarillo (AMA)to

Knoxville (TYS)
Depart: 10/24/2026
From
$269
Seen: 2 hrs ago
One-way
Basic

Colorado Springs (COS)to

Knoxville (TYS)
Depart: 10/29/2026
From
$312
Seen: 16 hrs ago
One-way
Basic

Corpus Christi (CRP)to

Knoxville (TYS)
Depart: 11/06/2026
From
$424
Seen: 8 hrs ago
One-way
Choice
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Discover Knoxville with Southwest Airlines

Book your next flight to Knoxville with Southwest Airlines and discover why East Tennessee is a destination filled with mountain beauty, vibrant culture, and Southern charm. Learn more about the Southwest® Experience and start planning your Knoxville getaway today.


Flying to Knoxville with Southwest Airlines

  • Enjoy easy access to East Tennessee with flights landing at Knoxville’s McGhee Tyson Airport (TYS), just minutes from downtown.
  • Arrive stress-free with Southwest’s convenient service and famously friendly hospitality.
  • With low fares and no hidden fees, Southwest makes getting to Knoxville as comfortable as the Southern charm that greets you.

Best Food & Drink in Knoxville

  • Start your day with a local favorite of biscuits smothered in sausage gravy or a made-from-scratch donut from a hometown bakery.
  • Enjoy a farm-to-table dinner at Market Square or take a short drive to Pigeon Forge for classic Southern comfort food and live dinner shows.
  • Taste Appalachian flavors inspired by the region’s mountain heritage and family recipes passed down for generations.

Find cheap flights to Knoxville

$

Nashville (BNA)to

Knoxville (TYS)
Depart: 11/14/2026

One-way

Basic

From
$59
Seen: 4 hrs ago

Houston Hobby (HOU)to

Knoxville (TYS)
Depart: 01/09/2027

One-way

Basic

From
$60
Seen: 1 hour ago

Baltimore/Washington (BWI)to

Knoxville (TYS)
Depart: 12/02/2026

One-way

Basic

From
$93
Seen: 20 hrs ago

Washington D.C. Reagan National (DCA)to

Knoxville (TYS)
Depart: 11/26/2026

One-way

Basic

From
$96
Seen: 2 hrs ago

Dallas-Love Field (DAL)to

Knoxville (TYS)
Depart: 01/09/2027

One-way

Basic

From
$110
Seen: 2 hrs ago

Hartford/Springfield (BDL)to

Knoxville (TYS)
Depart: 01/21/2027

One-way

Basic

From
$115
Seen: 21 hrs ago

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More Southwest flights to Knoxville