Southwest® flights from Knoxville starting at $139
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Book flights from Knoxville with Southwest Airlines
flight_land
$
Washington, D.C. (Reagan National) (DCA)to
Knoxville (TYS)Depart: 03/11/2026
From
$105
One-way
Basic
Chicago (Midway) (MDW)to
Knoxville (TYS)Depart: 03/10/2026
From
$105
One-way
Basic
Albuquerque (ABQ)to
Knoxville (TYS)Depart: 04/14/2026
From
$108
One-way
Basic
Baltimore/Washington (BWI)to
Knoxville (TYS)Depart: 03/10/2026
From
$109
One-way
Basic
Atlanta (ATL)to
Knoxville (TYS)Depart: 04/26/2026
From
$110
One-way
Basic
Houston (Hobby) (HOU)to
Knoxville (TYS)Depart: 06/24/2026
From
$115
One-way
Basic
Orlando (MCO)to
Knoxville (TYS)Depart: 03/11/2026
From
$119
One-way
Basic
Nashville (BNA)to
Knoxville (TYS)Depart: 03/19/2026
From
$119
One-way
Basic
Colorado Springs (COS)to
Knoxville (TYS)Depart: 04/14/2026
From
$125
One-way
Basic
Denver (DEN)to
Knoxville (TYS)Depart: 03/24/2026
From
$125
One-way
Basic
Jacksonville (JAX)to
Knoxville (TYS)Depart: 05/06/2026
From
$130
One-way
Basic
Cleveland (CLE)to
Knoxville (TYS)Depart: 04/25/2026
From
$134
One-way
Basic
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Book flights from Knoxville with Southwest Airlines
flight_takeoff
flight_land
$
Knoxville (TYS)to
Dallas (Love Field) (DAL)Depart: 02/22/2026
From
$139
Seen: 2 hrs ago
One-way
Basic
Knoxville (TYS)to
Orlando (MCO)Depart: 03/05/2026
From
$149
Seen: 2 hrs ago
One-way
Basic
Knoxville (TYS)to
Austin (AUS)Depart: 03/05/2026
From
$160
Seen: 14 hrs ago
One-way
Basic
Knoxville (TYS)to
Tampa (TPA)Depart: 03/05/2026
From
$160
Seen: 9 hrs ago
One-way
Basic
Knoxville (TYS)to
Atlanta (ATL)Depart: 03/05/2026
From
$195
Seen: 6 hrs ago
One-way
Basic
Knoxville (TYS)to
Phoenix (PHX)Depart: 03/05/2026
From
$219
Seen: 7 hrs ago
One-way
Basic
Knoxville (TYS)to
Orange County/Santa Ana (SNA)Depart: 03/05/2026
From
$229
Seen: 2 hrs ago
One-way
Basic
Knoxville (TYS)to
Portland, OR (PDX)Depart: 03/03/2026
From
$234
Seen: 54 minutes ago
One-way
Basic
Knoxville (TYS)to
Las Vegas (LAS)Depart: 03/02/2026
From
$305
Seen: 2 hrs ago
One-way
Basic
Knoxville (TYS)to
Sacramento (SMF)Depart: 03/05/2026
From
$414
Seen: 11 hrs ago
One-way
Choice
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Details about Mc Ghee Tyson Airport
Airport code:
TYS
City:
Knoxville
State:
Tennessee
Concourse:
0
Cities with weekly flights from TYS:
116†
Cities with daily nonstop flights Monday through Friday from TYS:
4‡
Cities with daily nonstop flights Saturday through Sunday from TYS:
10§
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 10/1/2025 and 10/31/2025.
Popular Destinations from Knoxville
flight_takeoff
flight_land
$
From | To | Fare Type | Dates | Price | |
|---|---|---|---|---|---|
| Knoxville (TYS) | Albuquerque (ABQ) | One-way / Basic | Depart: 03/18/2026 | From $108 Seen: 12 hrs ago | |
| Knoxville (TYS) | Albany (ALB) | One-way / Basic | Depart: 04/04/2026 | From $160 Seen: 4 hrs ago | |
| Knoxville (TYS) | Amarillo (AMA) | One-way / Basic | Depart: 04/07/2026 | From $177 Seen: 11 hrs ago | |
| Knoxville (TYS) | Atlanta (ATL) | One-way / Basic | Depart: 03/06/2026 | From $159 Seen: 6 hrs ago | |
| Knoxville (TYS) | Austin (AUS) | One-way / Basic | Depart: 05/04/2026 | From $160 Seen: 7 hrs ago | |
| Knoxville (TYS) | Hartford/Springfield (BDL) | One-way / Basic | Depart: 08/24/2026 | From $169 Seen: 8 hrs ago | |
| Knoxville (TYS) | Birmingham (BHM) | One-way / Basic | Depart: 08/23/2026 | From $159 Seen: 7 hrs ago | |
| Knoxville (TYS) | Nashville (BNA) | One-way / Basic | Depart: 03/10/2026 | From $119 Seen: 12 hrs ago |
*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.
Plan your trip
-
Rent a car.
Earn Rapid Rewards® points on your next rental car.
Rent a car -
Book a hotel.
Find deals for any season.
Book a hotel -
Plan a vacation.
Getaways by Southwest™ offers tons of vacation packages with amazing travel deals.
Book a vacation package
Join Rapid Rewards, our award-winning frequent flyer program1.
Sign up nowNo blackout dates.
You can use your points to book any seat, on any flight, no exceptions. Any day, any time, any flight, your points are ready to take you to where you want to go.
Your points don’t expire.
You can earn points on flights and on everyday purchases with our partners, which makes getting to your destination easy. No matter when, or where, you earn them, your points won’t expire.
Free inflight WiFi thanks to T-Mobile®.2
Rapid Rewards members can go online to check email, snag a dinner reservation, or browse social media from takeoff to landing. Learn more ›
12022–2023 Freddie Awards. 2Where available. Available only on WiFi-enabled designated aircraft. Free WiFi is only for Rapid Rewards® Members.
Discover popular routes from Knoxville
Explore More Flights
Explore Southwest Airlines® popular destinations